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Wednesday 13 November 2013

New Cholesterol Guidelines Abandon LDL Targets

WASHINGTON, DC – It's been more than a decade since theAdult Treatment Panel (ATP) issued the third report for the detection, evaluation, and treatment of elevated cholesterol and nine years since those recommendations were updated, but new guidelines from the American College of Cardiology(ACC) and American Heart Association (AHA), developed in conjunction with the National Heart, Lung, and Blood Institute (NHLBI), are now available online in both the Journal of the American College of Cardiology and Circulation [1].
And they contain some substantial changes from ATP 3.
Gone are the recommended LDL- and non-HDL–cholesterol targets, specifically those that ask physicians to treat patients with cardiovascular disease to less than 100 mg/dL or the optional goal of less than 70 mg/dL. According to the expert panel, there is simply no evidence from randomized, controlled clinical trials to support treatment to a specific target. As a result, the new guidelines make no recommendations for specific LDL-cholesterol or non-HDL targets for the primary and secondary prevention of atherosclerotic cardiovascular disease.
Instead, the new guidelines identify four groups of primary- and secondary-prevention patients in whom physicians should focus their efforts to reduce cardiovascular disease events. And in these four patient groups, the new guidelines make recommendations regarding the appropriate "intensity" of statin therapy in order to achieve relative reductions in LDL cholesterol.
No Evidence for Treating to Specific Targets
Dr Neil Stone (Northwestern University Feinberg School of Medicine, Chicago, IL), the chair of the expert panel who wrote the guidelines, spoke with the media during a conference call and said there were some problems with treating to goal, specifically in patients who were treated close but not exactly to target.
"In secondary prevention, what if your patient is on high-intensity statin therapy and gets an LDL-cholesterol level of 78 [mg/dL] and is adhering to an excellent lifestyle?" said Stone. "From our point of view, there is a large body of evidence that says he's actually doing as good a job as he can possibly do. If he has to get to an optional goal of under 70 [mg/dL] as some would advocate, it means adding on medicines for which there is not proven benefit."
In addition, the panel said that the use of LDL-cholesterol targets might result in the overtreatment of patients with nonstatin drugs. These other agents have not been shown to reduce the risk of atherosclerotic cardiovascular disease.
Dr Donald Lloyd-Jones (Northwestern University Feinberg School of Medicine), the cochair of the guidelines on the assessment of cardiovascular risk, which were also released today along with guidelines for the management and treatment of obesity and guidelines for lifestyle management, said the evidence for treating to target simply isn't there, but that doesn't mean repeated measurements of LDL cholesterol won't be needed.
"There have been no clinical trials in which they've taken an approach where they've titrated medication dosing to achieve a certain LDL level," said Lloyd-Jones. "We just haven't had those trials designed or performed yet. So we just couldn't endorse that kind of approach. And yet, we're not abandoning the measurement of LDL cholesterol, because it's perhaps our best marker of understanding whether patients are going to achieve as much benefit as they can for the dose of statin they can tolerate. For the clinician, it's also a very important marker of adherence."
Stone acknowledged that the old targets might be part of the "mind-set" of physicians but said the new recommendations actually simplify treatment in that doctors won't have to fuss around with additional means to lower LDL cholesterol if the patient has been treated with an appropriate dose of statin therapy.
Graham

6 comments:

Anonymous said...

I do find this confusing. Is it me are do others find the same?

Paul B

Anonymous said...

It seems to me they're saying they'll give up testing but carry on testing.

Continue with targets but ignore them.

No longer recommend statins but continue to dish them out to people who can still remember to their own name and move without pain.

Simple really!!!

Ray

Lowcarb team member said...

They obviously couldn't agree but rather than admitting it did the Obfuscation thing. Some of them love to fence-sit, that way they are always on the right side and can disclaim responsibility.

Patients may as well do their own thing as they get no proper guidance.
The arrogance!

Kath

Anonymous said...

I fear it is the case of, does anyone know what is going on?

This is confusing. Doctors are confused, those that sit on medical bodies are confused. Where does that leave the patient?

Well this one is sitting shaking her head.

Kay

Anonymous said...

'Patients may as well do their own thing as they get no proper guidance.'
Never a truer word spoken.!

Unknown said...

Here is Justin Smith (Station Nation)'s take on it:

http://www.statinnation.net/blog/2013/11/13/70-million-americans-set-to-take-a-statin-and-the-flawed-evidence