Statins are taken by more than 250,000 Irish people to help lower "bad cholesterol", a risk factor for heart disease and stroke.
However, a review by one of the country's leading vascular surgeons has found a lack of evidence to show that statins should be given as a means of prevention to healthy people who have high cholesterol but no heart disease.
Sherif Sultan, of University College Hospital in Galway, warned that statin use can increase the risk of diabetes, cataracts and male impotence.
"They can also significantly increase the risk of cancer and neurodegenerative disorders such as Parkinson's disease in the elderly, along with a myriad of infectious diseases," he said.
Mr Sultan said there were benefits in prescribing some dosages of statins for certain patients already diagnosed with heart disease or who had a history of heart attack or stroke.
However, otherwise healthy people with high cholesterol would do better losing weight, improving their diet, taking exercise and stopping smoking to avoid heart disease.
Mr Sultan and his colleague Niamh Hynes based their findings on a review of studies involving nearly 400,000 patients published in the 'Journal of Endocrine and Metabolic Diseases'.
He said his findings showed major adverse effects had been under-reported, which he said was a "scientific farce".
There is ample evidence to show statins increase cardiovascular risk in women, patients with diabetes and the young.
Too many doctors had fallen into the marketing trap behind the over-selling of statins and ignored side-effects linked to different doses, said Mr Sultan.
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